Police are appealing for public assistance to help locate missing 42-year-old Irie Findlay, 12-year-old Cooper Findlay, nine-year-old Chelsea Findlay and seven-year-old Cohen Findlay.
The children and their mother were last seen at a Berwick school on 10 December.
Investigators believe they may be travelling together in a silver Toyota Kluger with registration WEU630.
Police and family have concerns for their welfare due to lack of contact with family members and the childrens’ ages.
Police have released images of Irie, Cooper, Chelsea and Cohen in the hope someone recognises them or is aware of their location.
Anyone who sees Irie, Cooper, Chelsea, and Cohen is urged to contact Narre Warren Police Station on 9705 3111.