Police are currently at the scene of a fatal crash west of Apollo Bay, Victoria Police say.
It is believed a single vehicle was travelling along the Great Ocean Road when it failed to navigate a bend and struck a tree just after 2.30pm.
The car burst into flames.
The driver, who is believed to be the sole occupant of the vehicle and yet to be identified, died at the scene.
Investigations are ongoing.
The Great Ocean Road is currently closed in both directions between Lavers Hill and Apollo Bay.
Anyone with information or who may have witnessed the crash is urged to contact Crime Stoppers.