Police are at the scene of a single-vehicle crash in Altona Meadows, Victoria Police say.
It is believed a truck went off the road on a service lane near the Princes Freeway about 1.15pm and rolled.
Emergency services have freed a male driver, believed to be aged in his 40s, who was trapped in the cabin.
He has been taken to hospital in a critical condition.
The off ramp from the Princes Freeway to Point Cook Road remains closed.
Anyone who witnessed the crash is urged to call Crime Stoppers.
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