Police are appealing for public assistance to help locate missing Essendon woman Karen.
The 66-year-old was last seen at her residence on Royal Avenue about 1pm on Tuesday 4 January.
Police and family are concerned for Karen because she has a medical condition that requires daily medication.
Police have released an image of Karen in the hope someone recognises her and can provide information regarding her current whereabouts.
Anyone who sees Karen or has information on her whereabouts is urged to contact Moonee Ponds Police Station on (03) 9373 5200.
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