Police are investigating the circumstances of a fatal collision in Newborough this afternoon, Victoria Police say.
Investigators have been told a car travelling on the Princes Freeway on-ramp has collided with a truck travelling east on the Princes Freeway about 4pm.
The female driver of the car, who was the sole occupant, received life threatening injuries.
The woman was airlifted to hospital but died a short time later.
The male driver of the truck was not injured.
Anyone with information or who witnessed the crash should contact Crime Stoppers.