Arson Squad are investigating following a fatal house fire in Glen Waverley this morning.
Investigators have been told the fire started in the Tulloch Grove property just after 1.40am.
Sadly, a woman and three children have been located deceased at the residence and are yet to be formally identified.
A man was earlier able to escape and was taken to hospital with serious injuries.
The exact cause of the fire is yet to be determined and the investigation is ongoing.
Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or make a report at www.crimestoppersvic.com.au.