Detectives are investigating a disturbance in Brisbane City last night.
At 9.20pm, eight people gained entry to a hotel lobby by following guests in though the door.
During this time an altercation has ensued in a room which resulted in three of the eight people, an 18-year-old man and two 17-year-old boys, being wounded.
The trio were transported to the Princess Alexandra Hospital where the 18-year-old is being treated for life-threatening injuries.
An 18-year-old man is currently assisting police with inquiries.
Investigations are continuing.