Emergency services continue to work at the scene of the serious crash on State Highway 5, near Mamaku, about 20 minutes north of Rotorua, where a bus has rolled.
It is believed more than 20 people were on board the bus at the time of the crash.
A number of those passengers are reported to have been injured.
Patients are being transported to both Waikato and Rotorua.
Police can advise there have been fatalities in the crash, however the number cannot yet be confirmed.
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