Major Collision Investigation Unit detectives are investigating the circumstances surrounding a fatal crash in Somerton this morning.
It is understood a truck, which was travelling north on Hume Highway, was involved in a minor collision with a red sedan near Austrak Drive, about 7.45am.
The truck rolled and crashed into a pole.
Police were told the pole then fell onto a silver Honda, which was travelling the opposite way on the Hume Highway.
Emergency services worked on the female driver of the Honda, who is yet to be formally identified, but she sadly died at the scene.
The male truck driver was transported to hospital with non-life-threatening injuries.
The occupants of the red sedan were not injured.
Anyone who witnessed the collision, with CCTV/dashcam or information is urged to contact Crime Stoppers on 1800 333 000 or anonymously at www.crimestoppersvic.com.au