Police are investigating an incident at Royston Park.
At 2.45am Thursday 29 May police saw an incident occurring between a man and a woman on Payneham Road Royston Park.
As a result, police attempted to arrest the man who was restrained.
During his arrest he became unresponsive.
SA Ambulance attended the scene, and the man was taken to hospital where he remains.
Major Crime and Ethical and Professional Standards detectives are investigating the circumstances surrounding the incident.
The investigation is in the early stages and is ongoing.
More information will be released later this morning.
Any members of the public who witnessed or have footage of this incident are asked to call Crime Stoppers on 1800 333 000 or online at www.crimestopperssa.com.au