The Major Collision Investigation Unit are appealing for witnesses to a fatal collision in Robinvale yesterday.
Two vehicles, a light blue Toyota Camry and a dark grey Ford Falcon collided on the Murray Valley Highway near the corner of Crete Road shortly before 5pm.
Two passengers from the Toyota Camry, a 70-year-old Mildura woman and 5-year-old Mildura girl died at the scene.
The driver of the Toyota Camry, a 36-year-old Mildura man, and a 3-year-old Mildura boy were transported to hospital with non-life-threatening injuries.
The driver and sole occupant of the Ford Falcon, a 64-year-old Swan Hill woman was transported to hospital with non-life-threatening injuries.
An investigation into the cause of the collision is underway.
Investigators are appealing for anyone who saw the light blue Toyota Camry prior to the collision or anyone with dash cam footage to contact Crime Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au