Casey Highway Patrol officers are appealing for witnesses following a head-on collision in Keysborough this evening (18 April).
It is believed a dark Ford Mondeo and a white Toyota Kluger collided at the intersection of Chapel Road and Dandenong Bypass about 8.50pm.
The driver of the Ford, a 35-year-old Keysborough man, has been taken to hospital with non-life threatening injuries.
Two passengers of the other vehicle, a 41-year-old woman and 11-year-old girl from Brighton East, were taken to hospital with minor injuries.
The male driver and another passenger, also male, were not injured.
Police are yet to establish the exact circumstances surrounding the collision and the investigation is ongoing.
Investigators are urging anyone who witnessed the incident or who may have dash cam footage to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au