Police are appealing for public assistance to help locate missing Whittlesea woman Jessica Henne, Victoria Police say.
The 32-year-old was last seen at her Dunnart Boulevard residence on Monday night.
Police and family hold concerns for her welfare as her disappearance is out of character.
Investigators believe Jessica may be travelling in her Audi A4, registration QQB-933.
Police have released an image of Jessica in the hope someone may be able to provide information on her whereabouts.
Anyone who sights Jessica is urged to contact the Mill Park Police Station on 9407 3333.