Emergency services responded to a two-vehicle collision in Everton Upper this afternoon.
It's believed the vehicles collided on Beechworth-Wangaratta Road just after 3.30pm.
The yet to be formally identified driver of one vehicle died at the scene.
A female passenger of that car was taken to hospital with life-threatening injuries.
The female driver of the other vehicle was transported to hospital with life-threatening injuries.
A child, who was a passenger, was taken to hospital as a precaution.
The exact circumstances of the collision are yet to be determined, and investigations are ongoing.
Anyone who witnessed the incident, has dashcam footage or any other information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au
