Major Collision Investigation Unit detectives are investigating a fatal collision in Everton Upper yesterday.
It is believed a Mazda CX8 and Volkswagen Tiguan collided on Beechworth-Wangaratta Road just after 3.30pm.
The driver of the Volkswagen, a 74-year-old Beechworth woman, died at the scene.
Her female passenger was airlifted to hospital with life-threatening injuries.
The driver of the Mazda, a 41-year-old Beechworth woman, was airlifted to hospital with life-threatening injuries.
Her passenger, a 7-year-old girl, was airlifted to hospital as a precaution.
The exact circumstances of the collision are yet to be determined, and investigations are ongoing.
Anyone who witnessed the incident, has dashcam footage or any other information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au.