Greater Dandenong Highway Patrol officers continue to investigate after a motorcyclist was struck by a car in Noble Park last month.
Police will allege a grey Ford hatchback, and a grey Volkswagen Golf were seen racing each other on the Princes Highway on Thursday 22 May just before 2.30pm.
Both vehicles allegedly ran a red light, before the Ford struck a motorcyclist.
The male rider, 61-year-old Vermont South man, was taken to hospital with serious injuries where he remains.
The driver and a passenger of the Ford got out of the vehicle and fled the scene.
Police located the Volkswagen shortly after and arrested a man and a woman.
The 22-year-old Melton woman and 27-year-old Beaconsfield man have been charged with multiple offences including dangerous driving causing serious injury, recklessly cause serious injury and recklessly cause injury.
The woman has been remanded to appear in Melbourne Magistrates' Court on 15 August.
The man has been remanded to appear in Dandenong Magistrates' Court on 18 August.
It is understood the Volkswagen was allegedly bearing false registration plates.
Two male offenders remain outstanding, including the driver of the Ford Focus that allegedly struck the motorcyclist.
The first male is described as Caucasian with a slim build, approximately 30-years-old and wearing a black hoodie, black shorts, and white runners.
The second male is described as having an olive complexion, solid build, approximately 45-55-years-old and wearing a black short sleeve puffer jacket, dark t-shirt, blue jeans and had some sort of bag, possibly a dark coloured backpack with white writing over his shoulder.
Anyone who witnessed the collision or with dashcam is urged to call Crime Stoppers on 1800 333 000 or log onto www.crimestoppersvic.com.au.
