Fawkner Highway Patrol are seeking witnesses to a fatal collision this morning.
Police and emergency services were called to Campbellfield, following reports of a collision between a car and a truck.
It is believed a Nissan Patrol travelling north on Sydney Road collided with the rear of a truck just before 6.15am near the intersection of Truck City Drive.
The male driver and sole occupant of the Nissan, who is yet to be formally identified, died at the scene.
The driver of the truck, a 35-year-old man from Wyndham Vale, was unharmed and stopped to assist.
The investigation remains ongoing and investigators are appealing for anyone who witnessed the crash or who may have dashcam footage to contact Crime Stoppers on 1800 333 000.