Greensborough Highway Patrol are investigating following a two-car collision in Epping on Thursday evening.
Investigators have been told a silver Holden Commodore was observed by police travelling north on Edgars Road at a fast rate of speed when officers attempted to intercept the vehicle.
The vehicle failed to pull over and police did not pursue the vehicle.
A short time later, the vehicle collided into a black Hyundai at the intersection of cooper street about 10.20pm.
A driver of the Commodore, a 19-year-old Hampton Park man, was ejected from the vehicle and sustained serious injuries.
Two passengers, aged 19 and 21 both from Mt Evelyn, were taken to hospital with non-life-threatening injuries.
The driver of the Hyundai, a 27-year-old woman, sustained non-life-threatening injuries and was also taken to hospital.
Police are yet to determine the cause of the collision and area appealing to anyone who may have witnessed the collision or who has dash-cam footage to contact Crimes Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au