Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends against routine serologic screening for genital herpes simplex virus infection in asymptomatic adolescents and adults, including pregnant persons. Genital herpes is a common sexually transmitted infection caused by two related viruses, herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2). Infection is lifelong; currently, there is no cure for HSV infection. Antiviral medications may provide clinical benefits to symptomatic persons. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this statement is consistent with its 2016 recommendation.
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(doi:10.1001/jama.2023.0057)