Police are appealing for witnesses following a collision between a train and car in Bairnsdale tonight, Victoria Police say.
It is believed the incident occurred at a Ligar Street crossing about 6.30pm.
The two occupants in the car were trapped for some time before being cut free by emergency services.
The 19-year-old female driver, from Bairnsdale, has been airlifted to hospital in a serious but stable condition.
The 17-year-old male passenger, from Bairnsdale, has been airlifted to hospital in a critical condition.
None of the 38 passengers on board the V/Line Traralgon-bound train have reported any injuries.
The train line will remain closed until tomorrow morning while police investigate the cause of the collision.
Any witnesses or anyone with information is urged to contact Crime Stoppers.