An Emergency Alert flood message has been issued for residents in Douglas and Annandale.
Townsville City Council has advised intense rainfall may affect these areas, causing fast-moving and rapidly-rising water levels, leading to flash flooding.
Residents are advised to move to higher ground if they are concerned.
Those concerned are urged to evacuate immediately if safe to do so.
Evacuation centres are open at Heatley Secondary College on Fulham Road and Ignatius Park College on Ross River Road.
Contact Townsville City Council on 1800 738 541, listen to local radio or monitor the Townsville City Council website for more information www.townsville.qld.gov.au.