Global study finds extent of pharmaceutical pollution in world’s rivers

A new study looking at the presence of pharmaceuticals in the world’s rivers found concentrations at potentially toxic levels in more than a quarter of the locations studied.

The new study looked at 258 rivers across the globe, including the Thames in London and the Amazon in Brazil, to measure the presence of 61 pharmaceuticals, such as carbamazepine, metformin and caffeine.

The international team of researchers, including Lancaster University’s Dr Fabio Carvalho, studied rivers in over half of the world’s countries – with rivers in 36 of these countries having never previously been monitored for pharmaceuticals.

The study forms part of the University of York-led Global Monitoring of Pharmaceuticals Project, with the new study becoming the first truly global-scale investigation of medicinal contamination in the environment.

With their latest study, the researchers found that:

  • pharmaceutical pollution is contaminating water on every continent
  • strong correlations between the socioeconomic status of a country and higher pollution of pharmaceuticals in its rivers (with lower-middle income nations the most polluted)
  • high levels of pharmaceutical pollution was most positively associated with regions of high median age as well as high local unemployment and poverty rates
  • the most polluted countries and regions of the world are the ones that have been researched the least (namely sub-saharan Africa, South America and parts of southern Asia).
  • the activities most associated with the highest levels of pharmaceutical pollution included rubbish dumping along river banks, inadequate wastewater infrastructure and pharmaceutical manufacturing, and the dumping of the contents of residual septic tanks into rivers.

The study revealed that a quarter of the sites contained contaminants (such as sulfamethoxazole, propranolol, ciprofloxacin and loratadine) at potentially harmful concentrations.

The researchers hope that by increasing the monitoring of pharmaceuticals in the environment, they can develop strategies to limit the effects potentially caused by the presence of pollutants.

The study included noteworthy rivers such as the Amazon, Mississippi, Thames and the Mekong. Water samples were obtained from sites spanning from a Yanomami Village in Venezuela, where modern medicines are not used, to some of the most populated cities on the planet, such as Delhi, London, New York, Lagos, Las Vegas, and Guangzhou.

Areas of political instability such as Baghdad, the Palestinian West Bank and Yaoundé in Cameroon were also included. The climates where samples were obtained varied from high altitude alpine tundra in Colorado and polar regions in Antarctica, to Tunisian deserts.

While previous studies have monitored active pharmaceuticals ingredients (APIs) in rivers, these have ignored many of the countries of the world, have typically measured only a select few contaminants, and employed different analytical methods. Cumulatively, this has made it difficult to quantify the scale of the problem from a global perspective.

Dr Fabio Carvalho, of Lancaster Environment Centre, whose research interests include formulating standardised approaches to monitoring environmental change, was one of the co-authors of the study. He took samples along a 4km stretch of the River Trancão, north of Lisbon in Portugal – a stretch that flows through industrial, urban and rural landscapes.

He said: “This study highlights the scale of the problem of pharmaceutical water pollution worldwide, including in areas never previously studied. The standardised analytical approach adopted here allows for direct comparisons between rivers found under a variety of geographic, environmental and climatic conditions, as well as under different degrees of socio-economic pressures.

Crucially, the study underlines the importance of a global network of researchers working in collaboration to address questions relevant to solving current environmental problems. We managed to capture the influence of almost half a billion people on the aquatic health of some of the world’s main rivers with obvious implications for human health.

“The results provide vital data to help local stakeholders develop management strategies to mitigate the effects of water pollution on human health and the environment.”

The water sample analysis occurred at the University of York.

Co-leader of the project Dr John Wilkinson, from the University of York, said: “With 127 collaborators across 86 institutions worldwide, the Global Monitoring of Pharmaceuticals Project is an excellent example of how the global scientific community can come together to tackle large-scale environmental issues.

“We’ve known for over two decades now that pharmaceuticals make their way into the aquatic environment where they may affect the biology of living organisms. But one of the largest problems we have faced in tackling this issue is that we have not been very representative when monitoring these contaminants, with almost all of the data focused on a select few areas in North America, Western Europe and China.

“Through our project, our knowledge of the global distribution of pharmaceuticals in the aquatic environment has now been considerably enhanced. This one study presents data from more countries around the world than the entire scientific community was previously aware of: 36 new countries to be precise where only 75 had ever been studied before.”

The researchers suggest their approach could also be expanded in the future to include other environmental media such as sediments, soils and biota, and could allow for the development of global-scale datasets on pollution.

‘Pharmaceutical Pollution of the World’s Rivers’ is published in Proceedings of the National Academy of Science (PNAS).

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