About 9.30am, emergency services responded to reports a red Toyota Hilux utility and a white Volkswagen T-Cross station sedan had collided on Coral Bay Road, near Milinya-Exmouth Road.
The 25-year-old male driver of the Toyota Hilux was conveyed by paramedics to the Coral Bay Nursing Post with critical injuries but later died.
The 25-year-old female passenger of the same vehicle sustained minor injuries and was conveyed to Coral Bay Nursing Post for treatment.
The 50-year-old female driver and sole occupant of the Volkswagen sustained non-life-threatening injuries and was taken to Royal Perth Hospital for treatment.
Major Crash investigators are appealing for anyone with dash-cam or mobile phone vision, or other information relating to the crash to contact Crime Stoppers on 1800 333 000 or report online via www.crimestopperswa.com.au . Reports can be made anonymously.
If you or anyone you know has been affected by a road crash, contact Road Trauma Support WA on 1300 004 814.