About 6.20pm, a black Hyundai Getz and a black Triumph motorcycle collided at the intersection of Anketell Road and Kwinana Freeway.
The motorcycle rider, a 48-year-old man, sustained serious injuries and was conveyed to Royal Perth Hospital for treatment.
The driver of the Hyundai, an 18-year-old man, stopped at the scene and was uninjured.
Major Crash investigators are appealing for anyone with any information, or who saw either vehicle in the area prior to the crash to contact Crime Stoppers by submitting a report online at www.crimestopperswa.com.au , or by calling 1800 333 000.
Dash-cam or mobile phone vision relating to this crash can be uploaded directly to investigators via this link:
https://wapf.au.evidence.com/axon/community-request/public/anketell
If you or anyone you know has been affected by a road crash, contact Road Trauma Support WA on 1300 004 814.
The WA Police Force continues to urge all motorists to take care on the road. Drive safely and keep in mind the wellbeing of yourself and others.