Prahran Highway Patrol officers are investigating a serious collision in St Kilda this afternoon.
Emergency services responded to reports of a black BMW motorcycle and a grey Land Rover Discovery colliding at the intersection of Blessington Street and Marine Parade about 12pm.
The rider, a 35-year-old Glen Waverley man, was taken to hospital with life-threatening injuries.
The driver of the vehicle, a 57-year-old Malvern East man, was not injured and has been spoken to by police.
The investigation into the collision remains ongoing and police are appealing for any witnesses who were in the area at the time, including those who may have CCTV or dashcam of the incident to come forward.
Anyone who witnessed the incident, with footage or information is urged to contact Crime Stoppers on 1800 333 000 or anonymously at www.crimestoppersvic.com.au