Novel adjuvants assembled from a chemical construction set
© Wiley-VCH, re-use with credit to 'Angewandte Chemie' and a link to the original article.
To ensure that vaccines provide strong and lasting immunization, it is often necessary to supplement the actual vaccine (antigen) with additives that stimulate the immune system: adjuvants. Today, only a few substances have been approved for use as adjuvants. In the journal Angewandte Chemie, a research team has now introduced a spectrum of potential adjuvants. They started with the immune stimulant α-glactosyl ceramide (α-GalCer) and synthesized many different variants from a set of four building blocks.
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