Beijing Institute of Technology Press Co., Ltd
ALI, characterized by uncontrolled inflammation, oxidative stress, and fibrotic remodeling, remains a leading cause of morbidity and mortality worldwide. While MSCs hold promise for pulmonary repair due to their immunomodulatory and paracrine capabilities, clinical translation has been hindered by rapid clearance of systemically delivered cells and loss of therapeutic phenotype in conventional 2D culture. The new platform, led by Drs. Weixi Wang and Cong Ye, solves these issues through a bioengineered design that integrates 3D MSC culture with localized, adhesive delivery.
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