AstraZeneca will present new data advancing its ambition to redefine care at the 2022 San Antonio Breast Cancer Symposium (SABCS), 6-10 December 2022.
Twelve AstraZeneca medicines and potential new medicines will be featured in 55 presentations, including five oral presentations, showcasing the Company's growing leadership across different subtypes and stages of breast cancer.
Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: "Our data at SABCS are strong validation of our clinical strategy to provide next-generation treatment solutions for patients with nearly all major types of breast cancer. We are excited to share results from the pivotal CAPItello-291 trial, which will support the opportunity of our novel AKT inhibitor capivasertib for patients with HR-positive disease. We also look forward to presenting defining data from the SERENA-2 Phase II trial that will demonstrate the potential of our next-generation SERD camizestrant to improve upon currently available endocrine therapies for patients with ER-driven disease."
Dave Fredrickson, Executive Vice President, Oncology Business Unit, AstraZeneca, said: "As we close another year of breakthroughs in breast cancer, our presence at SABCS will showcase the opportunity for our portfolio to shape clinical practice and redefine care across subtypes and stages of this disease. Compelling results for potential new medicines capivasertib and camizestrant as well as new data from antibody drug conjugates Enhertu and datopotamab deruxtecan will underscore our focus on addressing the greatest unmet needs and delivering personalised treatment for more patients with breast cancer."
Aiming to set new standards of care across HER2-positive metastatic breast cancer
Two late-breaking presentations from the DESTINY-Breast clinical programme will highlight the efficacy of Enhertu (trastuzumab deruxtecan) treatment in patients with HER2-positive metastatic breast cancer across lines of therapy.
Updated results from the DESTINY-Breast03 Phase III trial of Enhertu versus trastuzumab emtansine (T-DM1) in patients with HER2-positive breast cancer previously treated with trastuzumab and a taxane will be presented, including updated progression-free survival (PFS) data and overall survival (OS) results.
In addition, primary results from the DESTINY-Breast02 Phase III trial will be presented, further demonstrating the clinical benefit of Enhertu compared to conventional chemotherapy-based regimens in patients with HER2-positive metastatic breast cancer previously treated with T-DM1.
Data will also be presented from the ROSET-BM retrospective study and DEBBRAH Phase II trial further confirming Enhertu activity in patients with HER2-positive or HER2-low metastatic breast cancer with active or stable brain metastases.
Reshaping treatment expectations in HR-positive advanced breast cancer
A late-breaking presentation will illustrate the Company's focus on addressing endocrine resistance in advanced HR-positive breast cancer.
Detailed data will be shared from the CAPItello-291 Phase III trial of the AKT inhibitor capivasertib in combination with Faslodex (fulvestrant) versus Faslodex alone in endocrine-resistant, HR-positive, HER2-low or negative advanced breast cancer. CAPItello-291 recently met both primary endpoints, demonstrating improvement in PFS in the overall patient population and in a prespecified biomarker subgroup of patients whose tumours had qualifying alterations in the PIK3CA, AKT1 or PTEN genes.
Several presentations will establish the clinical potential of the next-generation oral selective oestrogen receptor degrader (SERD) camizestrant as a monotherapy or in combination for patients with oestrogen receptor positive (ER-positive) advanced breast cancer.
- A late-breaking presentation will highlight detailed results from the positive SERENA-2 Phase II trial of camizestrant versus Faslodex in advanced ER-positive breast cancer.
- Analyses from further cohorts of the SERENA-1 Phase I trial of advanced ER-positive breast cancer will also be presented, which will show the potential to combine camizestrant with abemaciclib, a CDK4/6 inhibitor.
- A spotlight poster will feature data showing promising preclinical activity with camizestrant in ER-positive breast cancer when used in double and triple combinations with CDK4/6, mTOR, AKT or PI3K inhibitors, in ESR1 wild-type and mutated models.
Additionally, several presentations will showcase AstraZeneca's commitment to transforming the treatment landscape for HR-positive breast cancer with antibody drug conjugates (ADCs) and by identifying new tumour subtypes that may respond to targeted therapies.
- A poster presentation of results from the TROPION-PanTumor01 Phase I trial will characterise the safety and encouraging clinical activity of datopotamab deruxtecan in patients with heavily pre-treated HR-positive, HER2-negative inoperable or metastatic breast cancer. Datopotamab deruxtecan is also being tested in these patients in earlier lines of treatment in the randomised TROPION-Breast01 Phase III trial.
- Multiple poster presentations will share results for potential diagnostic tools to better identify and optimise treatment for patients across the spectrum of HER2 expression, including those with HER2-low tumours who may benefit from treatment with Enhertu.
- Data from various subgroup analyses from the DESTINY-Breast04 Phase III trial will reinforce the clinical meaningfulness of HER2-low as an actionable patient segment in patients with metastatic breast cancer.
Redefining care for triple-negative breast cancer (TNBC)
Two spotlight poster discussions will share results from the BEGONIA Phase Ib/II trial testing Imfinzi (durvalumab) combinations in advanced or metastatic TNBC, showing the potential to drive improved outcomes with the addition of ADCs.
Additionally, updated results from the TROPION-PanTumor01 Phase I trial of datopotamab deruxtecan monotherapy will show encouraging and durable anti-tumour activity, and a manageable safety profile in heavily pre-treated patients with metastatic TNBC. The TROPION-Breast02 Phase III trial is evaluating datopotamab deruxtecan as 1st-line therapy for patients with metastatic TNBC.
Enhertu and datopotamab deruxtecan are developed and commercialised in collaboration with Daiichi Sankyo worldwide, except in Japan where Daiichi Sankyo maintains exclusive rights.
Key AstraZeneca presentations during SABCS 2022
