Reston, VA (October 17, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
Summaries of the newly published research articles are provided below.
AI Tool Boosts PSMA PET/CT Consistency
Researchers tested aPROMISE, an AI-driven tool for interpreting PSMA PET/CT scans in 96 men with recurrent prostate cancer. Compared with a standard viewer, aPROMISE delivered similarly high intra- and interreader agreement and automatically segmented 92.1 percent of identified lesions, aligning closely with surgical histopathology results during PSMA-radioguided surgery across readers consistently.
PSMA PET Influences Treatment Choices in Prostate Cancer
Using data from more than 9,000 U.S. veterans, researchers examined how PSMA PET imaging affects initial treatment for newly diagnosed prostate cancer. Patients staged with PSMA PET were more likely to receive hormone-based therapies and less likely to undergo surgery, suggesting the scan's findings may shape real-world care decisions.
Brain Metabolic Changes Linked to Chemotherapy in Leukemia
In a study of 100 adults with leukemia, brain PET imaging revealed metabolic changes after chemotherapy, particularly in regions tied to cognition and emotion. Patients recently or previously treated showed decreased activity in several brain areas, with older adults and those receiving intrathecal therapy most affected.
FAP PET Shows Variable Uptake in Kidney Tumors
Researchers explored fibroblast activation protein (FAP) PET imaging in six patients with renal tumors. Uptake was highest in clear cell renal cell carcinoma and closely matched FAP expression seen under the microscope. The findings suggest differing FAP activity across kidney tumor types, supporting further investigation in larger studies.
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