Research
Research Background
CNS infections caused by carbapenem-resistant Enterobacteriaceae (CRE) pose a critical global healthcare challenge. These infections are exceptionally difficult to treat due to two major barriers: the blood-brain barrier (BBB), which blocks most antibiotics from reaching infection sites in the brain, and the protective biofilms produced by bacteria that significantly enhance antibiotic resistance. The World Health Organization has classified CRE as a priority pathogen, underscoring the urgent need for innovative treatment strategies.
Research Significance
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