About 10.15pm, a beige Chrysler 300 sedan and a grey Ford Falcon sedan collided at the intersection of Mandurah Road and Pinjarra Road.
The 18-year-old female driver of the Chrysler was conveyed by St John WA paramedics to Royal Perth Hospital with serious injuries.
A 16-year-old male passenger in the Chrysler was conveyed by St John WA paramedics to Peel Health Campus, where he later died.
The 34-year-old male driver of the Ford was not injured.
Major Crash investigators are appealing for any witnesses to make a report to Crime Stoppers online via www.crimestopperswa.com.au or by calling 1800 333 000.
Dash-cam or mobile phone vision relating to this crash can be uploaded directly to investigators via this link: https://wapf.au.evidence.com/axon/community-request/public/mandurahxpin…
If you or anyone you know has been affected by a road crash, contact Road Trauma Support WA on 1300 004 814.
