Serum aldosterone in patients with heart failure with preserved ejection fraction

Science China Press

Currently, patients with HFpEF have high risk of morbidity and mortality, but there is no effective measure for evaluating the prognosis. Studies have found that a variety of ways can lead to the development of HFpEF, including neurohormones or heart damage. Especially, aldosterone plays an important role in the development of heart failure. The renin- angiotensin- aldosterone system is activated, which stimulates aldosterone secretion from the adrenal cortex. The elevated aldosterone is associated with myocardial hypertrophy and fibrosis, leading to arterial stiffness, cardiac dysfunction, and risk of morbidity and mortality in heart failure. In this context, the association of serum aldosterone level with all-cause mortality and HF-hospitalization for patients with HFpEF is assessed.

“We demonstrate that level of serum aldosterone is independently associated with all-cause mortality (adjusted hazard ratio (aHR), 1.55; 95% confidence interval (95%CI) 1.06–2.27; P=0.024) and primary endpoint (aHR, 1.43; 95%CI 1.11–1.85; P=0.006) in HFpEF. ” said Dr. Bingbing Ke, the first author for this work. The results of this research indicate that aldosterone is an independent predictor of HFpEF prognosis. “The higher aldosterone level is associated with more risk of concentric left ventricular remodeling (adjusted odds ratio (aOR), 1.45; 95% CI 1.03–2.04; P=0.034), and poor prognosis. Moreover, patients with high aldosterone and BNP concentrations were at a higher risk of the primary endpoint (hazard ratio (HR), 1.85; 95%CI 1.29–2.66; P=0.001).” said Professor Jie Du, the co-corresponding author. Serum aldosterone concentrations provide a new measure for risk evaluation of all-cause mortality and HF re-hospitalization in HFpEF patients. Measurement of serum aldosterone concentration provides additive prognostic value when combined with BNP.

This work was supported by grants from the National Key Research and Development Program of China (2017YFC0908400) and the National Natural Science Foundation of China (91939303, 81790622, 81861128025).

See the article:

Bingbing, K., Xin, T., Lu, R., et al. (2021). Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction. Sci China Life Sci, in press, https://doi.org/10.1007/s11427-021-1945-6. This article was published online (https://engine.scichina.com/doi/10.1007/ s11427-021-1945-6), in the Science China Life Science, by Science China Press and Springer-Verlag Berlin Heidelberg.

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