"Bad" cholesterol isn't the only culprit linked with a higher risk of cardiovascular disease, according to a trio of recent University of Alberta studies — including landmark global research — showing that a different kind of cholesterol is also a strong risk factor for people worldwide.
Remnant cholesterol (RC) was confirmed as a strong risk factor for coronary heart disease, heart attacks and stroke, the largest of the studies showed. RC is produced from the metabolism of triglycerides that come from sources of dietary fat and from the body's own stores of cholesterol particles.
Using genomic data from a combined sample of almost one million participants — spanning Africa, Asia, North America and Europe — the findings are the first to show, on such a large scale, a causal link between high RC and risk of cardiovascular illness.
"This tells us that the health risk posed by high RC is of greater concern than the traditional LDL cholesterol which is our current goal of prevention and therapy," says Paolo Raggi, senior author of the study and professor of cardiology in the Faculty of Medicine & Dentistry.
The researchers found that having elevated RC led to a 1.5 times higher risk for coronary heart disease, a 1.6 times higher risk of heart attack and a 1.2 times higher risk of stroke.
A fuller picture of cardiovascular risk
Two studies drawing on Alberta data are also the first to confirm the relationship — and highlight the risk — of heart disease and high RC for the Canadian population.
High RC levels were linked with greater risk of developing heart disease, according to one of the studies, involving 14,000 middle-aged and older Albertans.
Additionally, the levels of RC were high regardless of whether people were already on medication for, or had normal or low levels of low-density lipoprotein cholesterol (LDL-C), commonly known as "bad" cholesterol, the research showed.
"We've provided new evidence that RC may be key in understanding the complete picture of cardiovascular risk and why people continue to have poor heart health despite achieving appropriate levels of LDL," says Spencer Proctor, a professor in the Division of Human Nutrition within the Faculty of Agricultural, Life & Environmental Sciences and one of the senior authors on the work.
"For the first time, we are showing that one of those risk factors could be RC."
Because medical screening for RC is less common than for LDL-C in Canada, it means the additional risk to people already susceptible to future heart attacks could be missed, says Proctor, who co-led the research team on the pair of Alberta studies, in collaboration with Dean Eurich, a professor in the U of A's School of Public Health.
"If LDL cholesterol is the only type measured and the level is found to be quite low — perhaps because it is being controlled by medication — that may seem like the risk of a cardiovascular event is lower. But that is an incomplete diagnostic picture, which should include assessment for RC."
Proctor, Eurich and their teams drew on data from the Alberta's Tomorrow Project, a long-term study that began tracking the health of 55,000 adults in the province in 2000, investigating why some people develop cancer and chronic diseases like heart disease and diabetes.
In analyzing the information, they found that people with heart disease had 15 per cent higher levels of RC in their blood, but not LDL-C levels, which were much lower, at seven per cent.
The results also showed that for every increase of one unit of RC in the blood, there was a 150 per cent higher risk of having an event such as a heart attack, versus a 73 per cent higher risk for LDL-C.
"LDL-C, in this case, isn't useful to predict future risk because people are possibly on medication," says Proctor.
