The Women's Irritability, Stress, and Estrogen (WISE) Study is seeking women 45-55 years of age in the menopause transition who are experiencing mood changes, particularly irritability, associated with the onset of menopause.
Participation for eligible women will entail:
- 1 in-person enrollment session and clinical interview
- 3 in-person laboratory EEG recording sessions
- Mood assessments
- Hormone (urine) samples
- 3 weeks of transdermal estradiol + 3 weeks of placebo patch - the order in which these are administered is randomized
Eligible participants may receive up to $650 in compensation.
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