In the battle against mosquito-borne diseases that kill hundreds of thousands of people each year, scientists turned to an unlikely ally: a fungus that smells like flowers.
Taking advantage of the mosquito's natural attraction to flowers, an international team of researchers engineered a new strain of Metarhizium fungus that imitates a flower's sweet scent and lures the bloodsucking bugs to their deaths.
Inspired by certain fungi that the team found emit a sweet-smelling chemical called longifolene to draw insect prey, they created what's essentially a deadly perfume for mosquitoes—offering new hope against malaria, dengue and other fatal diseases that traditional methods, like chemical pesticides, can no longer control. The researchers documented their invention and its ability to control mosquitoes in a new paper published in the journal Nature Microbiology on October 24, 2025.
"Mosquitoes need flowers because they provide nectar, a crucial source of food for them, and they are drawn to flowers through their scents," explained paper co-author Raymond St. Leger , a Distinguished University Professor of Entomology at the University of Maryland. "After observing that some types of fungi could trick mosquitoes into thinking they were flowers, we realized we could turbo-charge the attraction by engineering fungi to produce more longifolene, a sweet-smelling compound that's already very common in nature. Before this study, longifolene wasn't known to attract mosquitoes. We're letting nature give us a hint to tell us what works against mosquitoes."
St. Leger noted that the floral-scented fungus is an easy-to-use control method against mosquitoes, requiring little to no training or specialized knowledge. As soon as the fungus spores are placed in a container, either indoors or outdoors, longifolene is instantly and gradually released, maintaining effectiveness for months. Once mosquitoes encounter the fungus, they become infected and die within days. In lab tests, the fungus killed 90 to 100% of mosquitoes—even when placed in a large room with competing scents from humans and real flowers. Although the fragrant fungus is deadly to mosquitoes, it is harmless to humans.
"The fungus is completely harmless to humans as longifolene is already commonly used in perfumes and has a long safety record," St. Leger said. "This makes it much safer than many chemical pesticides. We've also designed the fungus and its containers to target mosquitoes specifically rather than any other insects and longifolene breaks down naturally in the environment."
In addition, unlike chemical alternatives that mosquitoes have gradually become resistant to, this biological approach may be nearly impossible for mosquitoes to outsmart or avoid.
"If mosquitoes evolve to avoid longifolene, that could mean they'll stop responding to flowers," St. Leger explained. "But they need flowers as a food source to survive, so it would be very interesting to see how they could possibly avoid the fungus yet still be attracted to the flowers they need. It'll be very difficult for them to overcome that hurdle, and we have the option of engineering the fungus to produce additional floral odors if they evolve to specifically avoid longifolene."
What also makes this new fungal technology particularly promising is how practical and affordable it is to produce. Other forms of Metarhizium are already commonly cultivated around the world on cheap materials like chicken droppings, rice husks and wheat scraps that are readily available after harvest. The affordability and simplicity of the fungus could be key to reducing mosquito disease-related deaths in many parts of the world, especially in poorer countries in the global south.
Finding effective new weapons against mosquitoes could be more important than ever. St. Leger warns that in the future, mosquito-borne diseases currently limited to tropical regions could threaten new targets, including the United States. With rising global temperatures and the growing unpredictability of weather, disease-carrying mosquitoes have begun to spread to new areas beyond their usual habitats.
"Mosquitoes love many of the ways we are changing our world," St. Leger said. "Right now, we're hoping to use these approaches in Africa, Asia and South America. But one day, we may need them for ourselves."
St. Leger and his collaborators are currently working on larger-scale outdoor trials of their mosquito control method to submit for regulatory approval.
"It's not as if you're going to necessarily find a silver bullet to control mosquitoes everywhere, but we're trying to develop a very diverse and flexible set of tools that people in different parts of the world can use and choose from," St. Leger said. "Different people will find different approaches work best for their particular situation and the particular mosquitoes they're dealing with. In the end, our goal is to give people as many options as possible to save lives."
