What: SRM 2925 is a frozen aqueous solution of recombinant human serum albumin (HSA). The SRM consists of two vials, each containing approximately 0.50 mL of frozen solution.
Why: Urine albumin is a major clinical biomarker of acute renal failure and chronic kidney disease. HSA is measured in human urine for clinical diagnosis of renal dysfunction and the evaluation of treatment efficacy.
Who: Clinical researchers and in-vitro diagnostics manufacturers working towards the accuracy and comparability of routine clinical urine albumin measurements.
How: SRM 2925 is intended for use as a primary reference calibrator for the quantification of HSA in human urine by LC-MS/MS measurement methods. This SRM can also be used to assess the accuracy of calibrators and control materials used for the quantification of HSA using LC-MS/MS measurement methods. An international certified reference material for HSA should improve the equivalence of measurement results between different measurement methods and across geographic locations.
