The Pacific Highway is closed in both directions between Nambucca Heads and Macksville after a fatal crash involving a heavy vehicle and a car, NSW Police say.
Emergency services were called to the scene about 4am tomorrow, and found a northbound B-double and a southbound sedan had collided in the northbound lanes.
A man driving the car died at the scene.
The truck driver has been taken to Macksville Hospital suffering shock. He will also undergo mandatory tests.
The highway is expected to be closed for some time while the site is examined and the wreckage is removed.
Motorists are advised to avoid the area as lengthy delays are expected.
Please check www.livetraffic.com for updates.
Police are urging anyone with information in relation to this incident to call Crime Stoppers.