New Mutation Causing Brain Disorder Uncovered

Researchers from the Hong Kong University of Science and Technology (HKUST) and Beijing Tiantan Hospital have recently uncovered a new gene mutation responsible for the non-familial patients of cerebral cavernous malformation (CCM) – a brain vascular disorder which inflicted about 10~30 million people in the world.

Prof. WANG Jiguang (front, seated) and his research team
Prof. WANG Jiguang (front, seated) and his research team

While the mutation of three genes: namely CCM1, CCM2, and CCM3, were known to be a cause of CCM – they mostly targeted patients who has family history in this disorder – which only account for about 20 per cent of the total inflicted population. The cause for the remaining 80 per cent non-familial cases, however, were not known.


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