Yale University
For decades, obesity medications produced only modest weight loss. But in recent years, Ozempic and related GLP-1 therapies have transformed the field, enabling sustained weight loss of 10 to 15% or more. Despite their success, however, scientists have not fully understood how these drugs work in the brain.
Now, in a new study, Yale researchers have identified an unexpected mechanism of action that challenges a long-held assumption about the brain's hunger circuitry: that agouti-related peptide (AgRP) neurons, known as drivers of hunger, functioned solely to oppose weight loss. However, the new study shows that GLP-1 therapies like Ozempic instead recruit these neurons to help sustain fat loss.
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