University of Southern California
A multidisciplinary USC research team has identified new compounds that may target a key driver of brain inflammation linked to Alzheimer's disease. Their research just published in the Nature publication npj Drug Discovery.
The driver is an enzyme called "calcium-dependent phospholipase A2," or cPLA2. The team discovered its role in brain inflammation by studying people who carry the APOE4 gene - the strongest genetic risk factor for Alzheimer's disease. While many people who have the APOE4 gene don't develop the disease, those with elevated levels of cPLA2 generally do.
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