About 2.25pm, a silver Ford Territory was travelling in an easterly direction on Muriel Street, near Cranwood Crescent, when it left the road and collided with a tree.
A 4-year-old female child and a 3-year-old female child were conveyed to Perth Children's Hospital for treatment of life-threatening injuries sustained.
The 24-year-old male driver of the vehicle and the 24-year-old female passenger were conveyed to Royal Perth Hospital for treatment of serious injuries received.
Major Crash investigators are conducting an examination of the scene and are appealing for any witnesses to contact Crime Stoppers online via www.crimestopperswa.com.au or by calling 1800 333 000.
Dash-cam or mobile phone vision relating to this crash can be uploaded directly to investigators via this link: https://wapf.au.evidence.com/axon/community-request/public/mcis2026-088… ;
If you or anyone you know has been affected by a road crash, contact Road Trauma Support WA on 1300 004 814.
The WA Police Force continues to urge all motorists to take care on the road. Drive safely and keep in mind the wellbeing of yourself and others.