Police are appealing for public assistance to help locate Guy and Susan Beesley.
The pair were last seen leaving an address in Whiteheads Creek, near Seymour about 12pm on Monday 28 October, bound for their home in Willung.
It is believed they were travelling in their white 2016 Land Rover Discovery Wagon, registered AJT 166.
They last made contact with family about 8.30am on Monday to advise they were intending to return home via Dinner Plain, however they have not returned home and have not made contact with family since.
Police and family have concerns for their welfare as their disappearance is out of character and due to the length of time they have been missing.
Guy is Caucasian and described as about 175cm tall with a medium build, is bald and has blue eyes.
He was last seen wearing dark coloured clothing.
Susan is Caucasian and described as about 165cm tall with a medium build, shoulder length straight blonde hair with a front fringe and hazel eyes.
She was last seen wearing a rust coloured t-shirt, skinny jeans and a black zip-up jacket with a grey quilted collar.
Police have released an image of the pair as well as their vehicle in the hope someone recognises them and can provide information on their whereabouts.
Anyone who sights Guy and Susan or their vehicle, or who knows of their whereabouts is urged to contact Benalla Police Station on 03 5760 0200.