UK Strep Research: Invasive Disease Incidence Shifts from Poorest to Second Affluent Group

European Society of Clinical Microbiology and Infectious Diseases

**Note: the release below is from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the conference if you use this story**

Measures introduced to reduce transmission of COVID-19 infections during 2020-2021 suppressed transmission of group A streptococcal (GAS) infections, particularly in children. Following the lifting of public health restrictions in the UK in Feb-2022, Group A Streptococcus presentations – including scarlet fever and invasive Group A Strep – rose significantly in England, although iGAS still remained very rare.

After a period of very high incidence in December 2022, scarlet fever notifications are now in line with what is expected at this time of year.However, iGAS notifications remain slightly higher than normally seen at this point in the season.

New research by UKHSA presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April) shows that while no new strains emerged in 2022, emm1, which is more likely to cause severe disease, was more common than in previous years.

Analysis of the populations impacted by the increase in infections found that pre-pandemic, iGAS incidence was higher in the most deprived quintiles, but post-pandemic the highest was in the second most affluent quintile. Further research is needed to understand the reasons for this.

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