Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians prescribe preexposure prophylaxis using effective antiretroviral therapy to persons at increased risk of HIV acquisition to decrease the risk of acquiring HIV. An estimated 1.2 million persons in the U.S. currently have HIV, and more than 760,000 persons have died of complications related to HIV since the first cases were reported in 1981. Although treatable, HIV is not curable and has significant health consequences. Therefore, effective strategies to prevent HIV are an important public health and clinical priority. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with its 2019 recommendation on PrEP for the prevention of HIV. For the current recommendation, the USPSTF reviewed additional evidence on new formulations of PrEP.
(doi:10.1001/jama.2023.14461)
