JAMA Network
About the Study: What is the global disease burden attributable to elevated low-density lipoprotein cholesterol (LDL-C)? In 2023, high LDL-C caused 3.6 million deaths (6.0% of all deaths) and 90.7 million disability-adjusted life years (DALYs) (3.2% of total DALYs). Despite declines of 45.6% in age-standardized mortality rates and 39.5% in DALY rates, the absolute LDL-C–related burden increased by 38.5% from 1990 to 2023, driven by population growth and aging, with notable regional disparities shifting toward middle-sociodemographic settings. Strategic approaches to prevent, diagnose, and treat elevated LDL-C across populations globally are needed.
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