A novel ε-poly-L-lysine-loaded sodium-alginate/gelatin hydrogel (PSG15) has shown exceptional promise in accelerating the healing of infected wounds. This multifunctional injectable hydrogel delivers robust antibacterial properties while regulating macrophage polarization and stabilizing the skin microbiota. It significantly inhibited bacterial growth, including that of E. coli and S. aureus, and promoted tissue regeneration in infected wounds. In animal models, PSG15 enhanced angiogenesis, collagen deposition, and wound closure. These findings demonstrate the potential of PSG15 as an effective treatment for infected wounds, offering both antibacterial action and microbiota stabilization to improve healing outcomes.
Infected wounds, particularly those caused by Escherichia coli and Staphylococcus aureus, pose significant challenges in clinical wound care. Traditional treatments often rely on antibiotics, but increasing bacterial resistance and potential toxicity limit their effectiveness. Hydrogels have emerged as a promising alternative due to their ability to deliver therapeutic agents locally. However, most existing hydrogels fail to address the dual challenge of infection and tissue repair effectively. This study explores a novel hydrogel that integrates ε-poly-L-lysine, a potent antimicrobial peptide, into a sodium alginate/gelatin matrix, offering a solution for both infection control and wound healing.
