NIR-Driven Nanomotors Boost Cancer Therapy

Beijing Institute of Technology Press Co., Ltd

The nanomotor starts with bowl‑shaped mesoporous polydopamine (PDA) nanoparticles. These biocompatible bowls are loaded with two key payloads: Fe(II) ions as a Fenton catalyst, and BNN6, a thermally sensitive NO donor. The resulting PFB nanoparticles are then cloaked with a fragment of MCF‑7 breast cancer cell membrane. "This membrane camouflage does two things," says Professor Hu. "It helps the nanomotor evade immune clearance, and it provides homologous targeting—the membrane proteins recognize and bind specifically to the same type of cancer cells."

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