Key takeaways
- A new randomised, double-blind crossover study of 74 healthy participants shows that a single night of road traffic noise can have measurable impacts on health.
- Participants exposed to nighttime traffic noise, typical of those living in a city, experienced impaired blood vessel function, raised heart rate, and blood protein changes linked to inflammation and stress responses.
- The findings, published in the journal Cardiovascular Research, could help explain why people exposed to long-term traffic noise have higher rates of high blood pressure and heart disease. The findings support calls for stricter noise regulation to improve cardiovascular health.
Sophia Antipolis, 26 February 2026: A new study published in the journal Cardiovascular Research shows that a single night of road traffic noise, at levels that are typical of those living in a city, causes stress to the heart and blood vessels.
The findings could help explain why people exposed to long-term traffic noise have higher rates of high blood pressure and heart disease.1
The randomised, double-blind crossover study of 74 healthy adults found that low-level nighttime road traffic noise impaired blood vessel function and raised heart rate, as well as disrupted sleep. The study also found blood protein changes linked to inflammation and stress in participants exposed to nighttime noise.
"Even a single night of road traffic noise stressed the cardiovascular system. We didn't expect to find such consistent biological changes in people exposed to noise levels typical of someone living near a road," explained lead author Dr. Omar Hahad from the University Medical Center of the Johannes Gutenberg-University in Germany.
The findings support calls from the European Society of Cardiology2 and the World Health Organization for stricter noise regulation. They underscore the need for urban planning that protects sleep and cardiovascular health in increasingly noise-polluted environments.
Seventy-four healthy participants took part for in the study for three nights. Each night they were exposed to one of three noise conditions: no noise (control), 30 episodes of traffic noise, or 60 episodes of traffic noise. The study was double-blinded which means that neither the participants, nor the researchers taking their health measurements knew which sound level conditions they were given each night.
The following morning the participants had a number of health tests, including flow mediated dilation, a standard test of blood vessel function. A lower percentage dilation of the blood vessels in this test indicates impaired blood vessel function and is associated with increased risk of cardiovascular disease. The flow-mediated dilation rate for the control group was 9.35%, whereas for participants exposed 30 incidents of nighttime traffic noise it was 8.19%, and for 60 nighttime noise events it was 7.73%.
Analysis of blood samples from participants exposed to noise showed changes in interleukin signalling and chemotaxis in participants who had also experienced the worst blood vessel effects. These changes are involved in inflammation and stress responses.
"These are similar key biological pathways that we find changed by noise in multiple mouse exposure studies, which means that we can now explain the molecular pathomechanisms induced by noise in humans by preclinical mechanistic insights" explained Prof. Andreas Daiber, Head of the Molecular Cardiology research group at the University Medical Center of the Johannes Gutenberg-University, and coordinator of the EU environmental research consortium MARKOPOLO.
Noise exposure also increased the mean heart rate of participants by a difference of 1.23 beats per minute. Self-reported sleep quality and restfulness were significantly reduced across all dimensions after exposure to noise.
"Even when we're asleep, our bodies are still listening. Repeated activation of stress responses night after night may help explain why people exposed to long-term traffic noise have higher rates of high blood pressure and heart disease. Protecting our sleep by tackling noise pollution should be part of how we think about preventing cardiovascular disease in towns and cities around the world." Dr. Hahad continued.
Participants were required to abstain from alcohol, caffeine, nicotine, recreational substances and strenuous physical activity throughout the study. They played the sound recordings in their bedroom overnight, with compliance monitored by continuous sound level recording. Traffic noises were real-life traffic recordings and each traffic noise event reached peak sounds of approximately 60 decibels.
Dr. Hahad explained the implications of the study for individuals and policymakers, "Reducing bedroom noise exposure where possible is a reasonable measure – by moving bedrooms away from the road or buying highly insulated windows. Earplugs might also reduce the noise burden, although we don't yet have solid evidence they protect against cardiovascular risks. Making lifestyle changes such as healthier diets and physical exercise would also be protective."
"However, the biggest positive impact would come from structural and societal measures, such as reducing traffic at night, quieter road surfaces, better urban planning, and good building insulation," he concluded.
Prof. Thomas Münzel, Senior author and Chair of the European Society of Cardiology Taskforce Environment and Sustainability commented: "Transportation noise should be formally recognised in future clinical practice guidelines on cardiovascular prevention as an independent, non-traditional cardiovascular risk factor, given consistent epidemiological and mechanistic evidence linking chronic exposure to hypertension, ischemic heart disease, stroke, and cardiometabolic dysfunction at levels below current regulatory thresholds."
The researchers note that this was a short-term study in young and healthy adults, and more research is needed to understand how these results relate to long-term risk of cardiovascular disease. They would like to confirm the changes to blood proteins in a larger study in future.
According to recent European Environment Agency (EEA) estimates3, approximately 150 million people, over 30% of the population in the European Economic Area, which includes all European Union member states as well as Iceland, Liechtenstein and Norway, are exposed to long-term unhealthy transportation noise levels (over 55 decibels Day-Evening-Night noise levels or Lden) when assessed against the World Health Organization's guideline values, with road traffic being the dominant contributor, accounting for the majority of exposed individuals.
Funding: Mainzer Wissenschaftsstiftung and Stiftung Mainzer Herz (TM).
Disclosures: OH, AD, and TM have nothing to disclose.
References and notes:
[1] Sorensen M, Raaschou-Nielsen O, Poulsen AH, Hvidtfeldt UA, Brandt J, Khan J, Jensen SS, Munzel T, Thacher JD. Long-term exposure to residential transportation noise and mortality: A nationwide cohort study. Environ Pollut 2023;328:121642.
[2] New EEA 2025 Noise Report Confirms: Environmental Noise is a Medical Emergency
[3] Environmental noise in Europe 2025. European Environment Agency, 2025.
