For those diagnosed with colorectal cancer, surgery has been the only option that offers a solution. Unfortunately, surgery is frequently complicated by disease recurrence at the site of the original cancer when microscopic cancer cells are left behind at the time of surgery. Chemotherapy is a treatment option that is often given in conjunction with surgery, although it can lead to toxic side effects.
Dr. Sung II Park, assistant professor in the Department of Electrical and Computer Engineering and researcher in the Center for Remote Health Technologies and Systems at Texas A&M University, and his team are working to develop a low cost, minimally invasive wireless device that offers precise, safe treatment options for cancers.
The researchers will utilize photodynamic therapy (PDT) during surgery by using a photosensitizer — a drug activated by light — to kill the cancer cells. During this process, surgeons will be able to remove the bulk of the tumor, then fully irradiate the tumor bed when the photosensitizer is activated by the light. This combination would result in a complete treatment in a safe and effective way with no toxic side effects.
"The biocompatible, miniaturized implantable LED device will enable light dosing and PDT that is tailored to the individual tumor response," Park said.
In the long term, the work will result in a platform that has the potential to provide clinical-quality health monitoring capabilities for continuous use beyond the confines of traditional hospital or laboratory facilities; it will also allow for treatment options to prevent the development of additional malignancy and therefore significantly improve the quality of life for people with cancer. This type of platform would also reduce the huge economic burden on oncology resources, which totaled $167 billion U.S. dollars in 2020 alone. In 2022, projected global oncology spending will reach $206 billion, a 23.35% increase.
