https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/16/issue/1
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Neg-entropy is the true drug target for chronic diseases by Rui Li, Tian-Le Gao, Gang Ren, Lu-Lu Wang and Jian-Dong Jiang ( https://doi.org/10.1016/j.apsb.2025.11.026 ). Chronic diseases are driven by increased biological entropy, so the authors propose targeting the body's inherent neg-entropic mechanisms (such as homeostasis, immunity, and self-healing) rather than isolated disease pathways. They introduce "head goose molecules" (HGMs) as key regulators of neg-entropy and propose the "HGMs–neg-entropy–dCloud" axis as a new drug discovery strategy that can reprogram disease processes and treat both symptoms and root causes.
Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis by Yaqi Yuan, Peng Jiang, Chuan Xiao, Jiapeng Lei, Bo Cheng, Hankun Hu and Wei Li ( https://doi.org/10.1016/j.apsb.2025.09.037 ). A dual-section microneedle patch is designed to enhance the therapeutic efficacy of psoriasis treatment via sustained release of triamcinolone acetonide and generation of oxygen for deep penetration of drugs.
Other articles include:
Reviews
Joshua Kramer, Eric Rohwer, Palaniappan Sethu, Min Xie, ... Jianhua Zhang
Yajun Wang, Ming Zhang, Wei Li
Xuquan Xian, Ruyi Gong, Shunzi Rong, Zhihao Zhang, ... Tao Jia
Computational approaches to druggable site identification: Current status and future perspective
Anqi Lin, Zhirou Zhang, Aimin Jiang, Kexin Li, ... Peng Luo
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design
Zhenzhen Zhou, Yanying Sun, Da Feng, Zhao Wang, ... Xinyong Liu
Omics-based large language models: A new engine for drug discovery innovation
Xia Sheng, Xiaoya Zhang, Yuxin Xing, Yuqi Shi, ... Xutong Li
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment
Nan Lin, Keqin Tan, Yuhao Wei, Songtao Xie, ... Xuelei Ma
Zheng Sun, Jun Ge, Hui Fu, Ziqiu Chen, ... Yingpeng Li
Concerns and challenges in clinics-guided nanovaccines design and applications
Yuhong Gao, Sijia Hua, Xiulin Dong, Kun Zhang, ... Jianfeng Yang
Original articles
Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects
Minju Han, Eunji Kim, Minchan Jeong, Solbi Kim, ... Heung Jin Jeon
Xuecen Wang, Yuxuan Zhao, Xingli Yang, Tingyu Liu, ... Xin Yue
Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke
Qiyuan An, Riqing Wei, Zhicheng Huang, Youyong Tang, ... Qiang Ma
Yu Zhu, Zhibi Zhang, Xueqin Dai, Wenjing Liu, ... Ceshi Chen
Deby Fajar Mardhian, Kunal P. Pednekar, Ahmed G. Hemdan, Praneeth Reddy Kuninty, ... Jai Prakash
Tao Yuan, Weihua Wang, Ruilin Wu, Yue Liu, ... Hong Zhu
Huanhuan Pang, Honglin Chen, Peng Chen, Xu Wei, ... Chengchao Xu
Wenting Wang, Yanfei Liu, Yiwen Li, Qian Xu, ... Yue Liu
Tong Che, Yixiang Chen, Xinyu Cheng, Han Hu, ... Bing Xiong
Hengyue Shan, Yuzheng Zhou, Ying Qin, Taijie Guo, ... Li Tan
Xue Liu, Yalan Lu, Qichen Chen, Minjian Yang, ... Xiaojian Wang
